Explore our research fingerprint
Jump over to the division’s research profile to fully explore the nature and scope of our research publications over the years.
Our labs
Horani Lab
Amjad Horani, MD
The Horani lab research focuses on airway epithelial cell differentiation and regulation with special interest in cilia assembly and how it relates to impaired mucociliary clearance and the biology of primary ciliary dyskinesia. The lab uses primary culture of human and mouse cells and employs genetic manipulation methods to investigate the function of novel proteins involved in ciliogenesis.
Rubenstein Lab
Ronald Rubenstein, MD, PhD
The Rubenstein lab focuses on the mechanisms by which small molecules may improve the function of mutant proteins that cause disease due to abnormal biogenesis and trafficking. These studies initially focused on epithelial ion channels relevant to Cystic Fibrosis, and have expanded to address fundamental biologic questions related to the regulation of protein biogenesis and trafficking in a number of other diseases and conditions.
Recent publications
- Airway Disease Modeling with Gene-Edited Human Basal Cell TransplantationBerical, A. C., Kiyokawa, H., Beermann, M. L., Wallman, D., Cherfane, G., Dunphy, V., Pan, J., Tilston-Lunel, A., Varelas, X., Horani, A., Brody, S. L., Kotton, D. N. & Hawkins, F. J., Jan 2025, In: American journal of respiratory and critical care medicine. 211, 1, p. 131-134 4 p.Research output: Contribution to journal › Letter › peer-review
- Caregiver worry about COVID-19 as a predictor of social mitigation behaviours and SARS-CoV-2 infection in a 12-city U.S. surveillance study of households with childrenOn behalf of the HEROS study group, Jan 2025, In: Preventive Medicine Reports. 49, 102936.Research output: Contribution to journal › Article › peer-review
- Lentiviral Gene Therapy for Cystic Fibrosis A Promising Approach and First-in-Human TrialDavies, J. C., Polineni, D., Boyd, A. C., Donaldson, S., Gill, D. R., Griesenbach, U., Hyde, S. C., Jain, R., McLachlan, G., Mall, M. A. & Alton, E. W. F. W., Dec 15 2024, In: American journal of respiratory and critical care medicine. 210, 12, p. 1398-1408 11 p.Research output: Contribution to journal › Review article › peer-review
- Host factors are associated with vaginal microbiome structure in pregnancy in the ECHO Cohort ConsortiumMcKee, K., Bassis, C. M., Golob, J., Palazzolo, B., Sen, A., Comstock, S. S., Rosas-Salazar, C., Stanford, J. B., O’Connor, T., Gern, J. E., Paneth, N., Dunlop, A. L., Smith, P. B., Newby, L. K., Adair, L., Jacobson, L. P., Catellier, D., McGrath, M., Douglas, C. & Duggal, P. & 271 others, Knapp, E., Kress, A., Blackwell, C. K., Mansolf, M. A., Lai, J. S., Ho, E., Cella, D., Gershon, R., Macy, M. L., Das, S. R., Freedman, J. E., Mallal, S. A., McLean, J. A., […]
- Do small effects matter more in vulnerable populations? an investigation using Environmental influences on Child Health Outcomes (ECHO) cohortson behalf of program collaborators for Environmental influences on Child Health Outcomes, Dec 2024, In: BMC Public Health. 24, 1, 2655.Research output: Contribution to journal › Article › peer-review
- Comparison of Longitudinal Outcomes in Children with Primary Ciliary Dyskinesia and Cystic FibrosisGenetic Disorders of Mucociliary Clearance Consortium, Dec 2024, In: Annals of the American Thoracic Society. 21, 12, p. 1723-1732 10 p.Research output: Contribution to journal › Article › peer-review
- A Preterm Infant with an Unlucky AirwayLalos, N., Thamrongsak, C., Friedman, H. & Brennan, S. K., Dec 2024, In: NeoReviews. 25, 12, p. e812-e815Research output: Contribution to journal › Article › peer-review
- Race and Ethnicity, Gender, and Promotion of Physicians in Academic MedicineClark, L., Shergina, E., Machado, N., Scheuermann, T. S., Sultana, N., Polineni, D., Shih, G. H., Simari, R. D., Wick, J. A. & Richter, K. P., Nov 27 2024, In: JAMA Network Open. 7, 11, p. e2446018Research output: Contribution to journal › Article › peer-review
- Race, Gender, and Faculty Retention in Academic MedicineScheuermann, T. S., Clark, L., Sultana, N., Machado, N., Shergina, E., Polineni, D., Shih, G. H., Simari, R. D., Wick, J. A. & Richter, K. P., Nov 4 2024, In: JAMA Network Open. 7, 11, p. e2445143Research output: Contribution to journal › Article › peer-review
- scRNA-seq profiling of human granulocytes reveals expansion of developmentally flexible neutrophil precursors with mixed neutrophil and eosinophil properties in asthmaHaruna, N. F., Politanska, Y., Connelly, A. R., O'Connor, K., Bhattacharya, S., Miklaszewski, G. E., Pérez-Leonor, X. G., Rerko, G., Hentenaar, I. T., Nguyen, D. C., Lamothe Molina, P. A., Bochner, B. S., Abdala-Valencia, H., Gill, M. A., Lee, F. E. H. & Berdnikovs, S., Nov 4 2024, In: Journal of Leukocyte Biology. 116, 5, p. 1184-1197 14 p.Research output: Contribution to journal › Article › peer-review