Our labs
Horani Lab
Amjad Horani, MD
The Horani lab research focuses on airway epithelial cell differentiation and regulation with special interest in cilia assembly and how it relates to impaired mucociliary clearance and the biology of primary ciliary dyskinesia. The lab uses primary culture of human and mouse cells and employs genetic manipulation methods to investigate the function of novel proteins involved in ciliogenesis.
Rubenstein Lab
Ronald Rubenstein, MD, PhD
The Rubenstein lab focuses on the mechanisms by which small molecules may improve the function of mutant proteins that cause disease due to abnormal biogenesis and trafficking. These studies initially focused on epithelial ion channels relevant to Cystic Fibrosis, and have expanded to address fundamental biologic questions related to the regulation of protein biogenesis and trafficking in a number of other diseases and conditions.
Publications
Recent publications
- Dysregulation of airway and systemic interferon responses promotes asthma exacerbations in urban childrenGaberino, C. L., Altman, M. C., Gill, M. A., Bacharier, L. B., Gruchalla, R. S., O'Connor, G. T., Kumar, R., Khurana Hershey, G. K., Kattan, M., Liu, A. H., Teach, S. J., Zoratti, E. M., Becker, P. M., Togias, A., Visness, C., Gern, J. E., Busse, W. W. & Jackson, D. J., May 2025, In: Journal of Allergy and Clinical Immunology. 155, 5, p. 1499-1509 11 p.Research output: Contribution to journal › Article › peer-review
- Genetic Testing Utilization in the U.S. Registry for Childhood Interstitial and Diffuse Lung Diseasesfor the chILD Registry Collaborative, Apr 2025, In: Pediatric Pulmonology. 60, 4, e71073.Research output: Contribution to journal › Article › peer-review
- Comparison of Race-Neutral versus Race-Specific Spirometry Equations for Evaluation of Child AsthmaECHO Cohort Consortium, Mar 1 2025, In: American journal of respiratory and critical care medicine. 211, 3, p. 464-476 13 p.Research output: Contribution to journal › Article › peer-review
- Vanzacaftor–tezacaftor–deutivacaftor for children aged 6–11 years with cystic fibrosis (RIDGELINE Trial VX21-121-105): an analysis from a single-arm, phase 3 trialVX21-121-105 Study Group, Mar 2025, In: The Lancet Respiratory Medicine. 13, 3, p. 244-255 12 p.Research output: Contribution to journal › Article › peer-review
- Diagnostic alignment to optimize inter-rater reliability among lung transplant pathologistsOn behalf of the Clinical Trials and Organ Transplantation (CTOT)-47 consortium, Feb 2025, In: Journal of Heart and Lung Transplantation. 44, 2, p. 173-181 9 p.Research output: Contribution to journal › Article › peer-review
- Undocking of an extensive ciliary network induces proteostasis and cell fate switching resulting in severe primary ciliary dyskinesiaBrody, S. L., Pan, J., Huang, T., Xu, J., Xu, H., Koenitizer, J. R., Brennan, S. K., Nanjundappa, R., Saba, T. G., Rumman, N., Berical, A., Hawkins, F. J., Wang, X., Zhang, R., Mahjoub, M. R., Horani, A. & Dutcher, S. K., Jan 29 2025, In: Science translational medicine. 17, 783, eadp5173.Research output: Contribution to journal › Article › peer-review
- Inhaled Reliever Therapies for AsthmaRayner, D. G., Ferri, D. M., Guyatt, G. H., O’Byrne, P. M., Brignardello-Petersen, R., Foroutan, F., Chipps, B., Sumino, K., Perry, T. T., Nyenhuis, S., Oppenheimer, J., Israel, E., Hoyte, F., Rivera-Spoljaric, K., McCabe, E., Rangel, S., Shade, L. E., Press, V. G., Hall, L. & Sue-Wah-Sing, D. & 9 others, Melendez, A., Orr, H., Winders, T., Gardner, D. D., Przywara, K., Rank, M. A., Bacharier, L. B., Mosnaim, G. & Chu, D. K., Jan 14 2025, In: JAMA. 333, 2, p. 143-152 10 p.Research output: Contribution to journal › Article › peer-review
- Using Community Engagement to Create a Telecoaching Intervention to Improve Self-Management in Adolescents and Young Adults With Cystic Fibrosis: Qualitative StudyDuncan, C. L., Muther, E. F., Lindwall, J. J., Durkin, K., Ruvalcaba, E., Williamson, E., Ahrabi-Nejad, C., Bord, E., Green, A., Harrison, M. L. & Polineni, D., 2025, In: Journal of Participatory Medicine. 17, e49941.Research output: Contribution to journal › Article › peer-review
- Association Between Prenatal Antibiotic Exposure and Infant Wheeze Outcomesprogram collaborators for Environmental influences on Child Health Outcomes, 2025, (Accepted/In press) In: Acta Paediatrica, International Journal of Paediatrics.Research output: Contribution to journal › Article › peer-review
- C-Reactive Protein Changes in Adult and Pediatric People With Cystic Fibrosis During Treatment of Pulmonary ExacerbationsZuckerman, J. B., Hinton, A. C., Lahiri, T., Teneback, C. C., Jia, S., Mermis, J., Polineni, D., Dasenbrook, E., Sadeghi, H., DiMango, E., Dezube, R., West, N. E., Zemanick, E. T., Samya, Z. N. & Gifford, A. H., Jan 2025, In: Pediatric Pulmonology. 60, 1, e27487.Research output: Contribution to journal › Article › peer-review