Our labs
Horani Lab
Amjad Horani, MD
The Horani lab research focuses on airway epithelial cell differentiation and regulation with special interest in cilia assembly and how it relates to impaired mucociliary clearance and the biology of primary ciliary dyskinesia. The lab uses primary culture of human and mouse cells and employs genetic manipulation methods to investigate the function of novel proteins involved in ciliogenesis.
Polineni Lab
Deepika Polineni, MD, MPH
Our lab investigates the biological mechanisms behind the variability in lung disease severity among people with cystic fibrosis (pwCF), focusing on non-CFTR factors that influence inflammatory and immune responses in CF airway epithelia using cell-culture models. Utilizing techniques from molecular biology, biochemistry, genetics, and bioinformatics, we aim to better understand these variables and their impact on the disease.
Rubenstein Lab
Ronald Rubenstein, MD, PhD
The Rubenstein lab focuses on the mechanisms by which small molecules may improve the function of mutant proteins that cause disease due to abnormal biogenesis and trafficking. These studies initially focused on epithelial ion channels relevant to Cystic Fibrosis, and have expanded to address fundamental biologic questions related to the regulation of protein biogenesis and trafficking in a number of other diseases and conditions.
Publications
Recent publications
- A protein complex in the extreme distal tip of vertebrate motile cilia controls their organization, length, and functionHong, J., Lee, C., Madhu, G., Papoulas, O., Atayeter, E., Hoogerbrugge, G., Pan, J., Takagishi, M., Manzi, N. I., Dickinson, D. J., Horani, A., Brody, S., Marcotte, E. M., Prakash, V. N., Park, T. J. & Wallingford, J. B., Dec 2026, In: Nature communications. 17, 1, 394.Research output: Contribution to journal › Article › peer-review
- Immune development in urban children and its relationship to environmental exposures, allergic sensitization, and asthmaGern, J. E., Schwartz, J., Yee, J., Bacharier, L., Kattan, M., O'Connor, G. T., Rivera-Spoljaric, K., Wood, R. A., Calatroni, A., Gergen, P. & Craven, M., Jan 2026, In: Journal of Allergy and Clinical Immunology. 157, 1, p. 226-237 12 p.Research output: Contribution to journal › Article › peer-review
- Mepolizumab alters gene regulatory networks of nasal airway type-2 and epithelial inflammation in urban children with asthmaGaberino, C. L., Segnitz, R. M., Dill-McFarland, K. A., Bacharier, L. B., Calatroni, A., Gill, M. A., Stokes, J., Liu, A. H., Cohen, R. T., Kumar, R., Lang, A., Khurana Hershey, G. K., Sherenian, M. G., Zoratti, E. M., Teach, S. J., Kattan, M., Becker, P. M., Togias, A., Busse, W. W. & Jackson, D. J. & 1 others, Altman, M. C., Dec 2025, In: Nature communications. 16, 1, 8191.Research output: Contribution to journal › Article › peer-review
- European Respiratory Society and American Thoracic Society guidelines for the diagnosis of primary ciliary dyskinesiaShoemark, A., Goutaki, M., Kinghorn, B. A., Ardura-Garcia, C., Baz-Redón, N., Chilvers, M., Davis, S. D., De Brandt, J., Dell, S., Dhar, R., Dixon, L., Ferkol, T., Hogg, C., Legendre, M., Leigh, M., Lucas, J. S., Manion, M., Rumman, N., Toews, I. & Labonte, V. & 3 others, Wee, W. B., Kouis, P. & Horani, A., Dec 1 2025, In: The European respiratory journal. 66, 6Research output: Contribution to journal › Article › peer-review
- Whole-genome sequencing reveals individual and cohort level insights into chromosome 9p syndromes9P-ARCH, Dec 2025, In: Genome medicine. 17, 1, 129.Research output: Contribution to journal › Article › peer-review
- Association of Maternal Prepregnancy BMI With Offspring Cardiometabolic Outcomes in Childhoodprogram collaborators for Environmental influences on Child Health Outcomes, Dec 2025, In: Obesity. 33, 12, p. 2330-2344 15 p.Research output: Contribution to journal › Article › peer-review
- Clinical Effectiveness of Elexacaftor/Tezacaftor/Ivacaftor in 6-to 11-Year-Olds with Cystic Fibrosis An Observational Studythe PROMISE Pediatric substudy Investigators, Nov 1 2025, In: Annals of the American Thoracic Society. 22, 11, p. 1696-1708 13 p.Research output: Contribution to journal › Article › peer-review
- New Treatments Are Urgently Needed for Patients With All Primary Ciliary Dyskinesia GenotypesGaston, B., Horani, A., Davis, S., Ferkol, T., Kinghorn, B. A., Rosenfeld, M., Shapiro, A., Machogu, E., O'Connor, M., Holme, H. & Manion, M., Nov 2025, In: Pediatric Pulmonology. 60, 11, e71372.Research output: Contribution to journal › Letter › peer-review
- Dynaps and cytoplasmic assembly of axonemal dyneinsWallingford, J. B., Brody, S. L., Horani, A. & Lee, C., Oct 2025, In: Journal of cell science. 138, 20, jcs264137.Research output: Contribution to journal › Article › peer-review
- The Impact of COronaVIrus Disease of 2019 Pandemic on Home Health Nursing Availability in Pediatric Patients After Tracheostomy PlacementCacho, F., Carr, K. A., Bedoya, M. & Kaslow, J. A., Sep 2025, In: Pediatric Pulmonology. 60, 9, e71273.Research output: Contribution to journal › Article › peer-review