Research

Explore our research fingerprint

Jump over to the division’s research profile to fully explore the nature and scope of our research publications over the years.

Complete research profile

Our labs

Gill Lab

Michelle Gill, MD, PhD

Research profile

Horani Lab

Amjad Horani, MD

The Horani lab research focuses on airway epithelial cell differentiation and regulation with special interest in cilia assembly and how it relates to impaired mucociliary clearance and the biology of primary ciliary dyskinesia. The lab uses primary culture of human and mouse cells and employs genetic manipulation methods to investigate the function of novel proteins involved in ciliogenesis.

Research profile

Polineni Lab

Deepika Polineni, MD, MPH

Research profile

Rubenstein Lab

Ronald Rubenstein, MD, PhD

The Rubenstein lab focuses on the mechanisms by which small molecules may improve the function of mutant proteins that cause disease due to abnormal biogenesis and trafficking. These studies initially focused on epithelial ion channels relevant to Cystic Fibrosis, and have expanded to address fundamental biologic questions related to the regulation of protein biogenesis and trafficking in a number of other diseases and conditions.

Research profile

Recent publications

  • Diagnostic alignment to optimize inter-rater reliability among lung transplant pathologists
    Diagnostic alignment to optimize inter-rater reliability among lung transplant pathologistsOn behalf of the Clinical Trials and Organ Transplantation (CTOT)-47 consortium, Feb 2025, In: Journal of Heart and Lung Transplantation. 44, 2, p. 173-181 9 p.Research output: Contribution to journal › Article › peer-review
  • Undocking of an extensive ciliary network induces proteostasis and cell fate switching resulting in severe primary ciliary dyskinesia
    Undocking of an extensive ciliary network induces proteostasis and cell fate switching resulting in severe primary ciliary dyskinesiaBrody, S., Pan, J., Huang, T., Xu, J., Xu, H., Koenitizer, J. R., Brennan, S., Nanjundappa, R., Saba, T. G., Rumman, N., Berical, A., Hawkins, F. J., Wang, X., Zhang, R., Mahjoub, M. R., Horani, A. & Dutcher, S. K., Jan 29 2025, In: Science translational medicine. 17, 783, eadp5173.Research output: Contribution to journal › Article › peer-review
  • Using Community Engagement to Create a Telecoaching Intervention to Improve Self-Management in Adolescents and Young Adults With Cystic Fibrosis: Qualitative Study
    Using Community Engagement to Create a Telecoaching Intervention to Improve Self-Management in Adolescents and Young Adults With Cystic Fibrosis: Qualitative StudyDuncan, C. L., Muther, E. F., Lindwall, J. J., Durkin, K., Ruvalcaba, E., Williamson, E., Ahrabi-Nejad, C., Bord, E., Green, A., Harrison, M. L. & Polineni, D., 2025, In: Journal of Participatory Medicine. 17, e49941.Research output: Contribution to journal › Article › peer-review
  • Airway Disease Modeling with Gene-Edited Human Basal Cell Transplantation
    Airway Disease Modeling with Gene-Edited Human Basal Cell TransplantationBerical, A. C., Kiyokawa, H., Beermann, M. L., Wallman, D., Cherfane, G., Dunphy, V., Pan, J., Tilston-Lunel, A., Varelas, X., Horani, A., Brody, S. L., Kotton, D. N. & Hawkins, F. J., Jan 2025, In: American journal of respiratory and critical care medicine. 211, 1, p. 131-134 4 p.Research output: Contribution to journal › Letter › peer-review
  • Efficacy and safety of LAU-7b in a Phase 2 trial in adults with cystic fibrosis
    Efficacy and safety of LAU-7b in a Phase 2 trial in adults with cystic fibrosisstudy Investigators, Konstan, M. W., Polineni, D., Chmiel, J. F., Bilodeau, L., Middleton, P. G., Matouk, E., Houle, J. M., Pislariu, R., Colin, P., Kianicka, I., Potvin, D., Radzioch, D., Kotsimbos, T., Zuckerman, J. B., Nasr, S. Z., Liou, T. G. & Lands, L. C., Jan 2025, In: Journal of Cystic Fibrosis. 24, 1, p. 83-90 8 p.Research output: Contribution to journal › Article › peer-review
  • Caregiver worry about COVID-19 as a predictor of social mitigation behaviours and SARS-CoV-2 infection in a 12-city U.S. surveillance study of households with children
    Caregiver worry about COVID-19 as a predictor of social mitigation behaviours and SARS-CoV-2 infection in a 12-city U.S. surveillance study of households with childrenOn behalf of the HEROS study group, Jan 2025, In: Preventive Medicine Reports. 49, 102936.Research output: Contribution to journal › Article › peer-review
  • C-Reactive Protein Changes in Adult and Pediatric People With Cystic Fibrosis During Treatment of Pulmonary Exacerbations
    C-Reactive Protein Changes in Adult and Pediatric People With Cystic Fibrosis During Treatment of Pulmonary ExacerbationsZuckerman, J. B., Hinton, A. C., Lahiri, T., Teneback, C. C., Jia, S., Mermis, J., Polineni, D., Dasenbrook, E., Sadeghi, H., DiMango, E., Dezube, R., West, N. E., Zemanick, E. T., Samya, Z. N. & Gifford, A. H., Jan 2025, In: Pediatric Pulmonology. 60, 1, e27487.Research output: Contribution to journal › Article › peer-review
  • Lentiviral Gene Therapy for Cystic Fibrosis A Promising Approach and First-in-Human Trial
    Lentiviral Gene Therapy for Cystic Fibrosis A Promising Approach and First-in-Human TrialDavies, J. C., Polineni, D., Boyd, A. C., Donaldson, S., Gill, D. R., Griesenbach, U., Hyde, S. C., Jain, R., McLachlan, G., Mall, M. A. & Alton, E. W. F. W., Dec 15 2024, In: American journal of respiratory and critical care medicine. 210, 12, p. 1398-1408 11 p.Research output: Contribution to journal › Review article › peer-review
  • A Preterm Infant with an Unlucky Airway
    A Preterm Infant with an Unlucky AirwayLalos, N., Thamrongsak, C., Friedman, H. & Brennan, S. K., Dec 2024, In: NeoReviews. 25, 12, p. e812-e815Research output: Contribution to journal › Article › peer-review
  • Host factors are associated with vaginal microbiome structure in pregnancy in the ECHO Cohort Consortium
    Host factors are associated with vaginal microbiome structure in pregnancy in the ECHO Cohort ConsortiumMcKee, K., Bassis, C. M., Golob, J., Palazzolo, B., Sen, A., Comstock, S. S., Rosas-Salazar, C., Stanford, J. B., O’Connor, T., Gern, J. E., Paneth, N., Dunlop, A. L., Smith, P. B., Newby, L. K., Adair, L., Jacobson, L. P., Catellier, D., McGrath, M., Douglas, C. & Duggal, P. & 271 others, Knapp, E., Kress, A., Blackwell, C. K., Mansolf, M. A., Lai, J. S., Ho, E., Cella, D., Gershon, R., Macy, M. L., Das, S. R., Freedman, J. E., Mallal, S. A., McLean, J. A., […]