Research
Primary research for the Rare Lung Disease Center is conducted through the lab of Amjad Horani, MD.
Horani Lab
Amjad Horani, MD
The Horani lab research focuses on airway epithelial cell differentiation and regulation with special interest in cilia assembly and how it relates to impaired mucociliary clearance and the biology of primary ciliary dyskinesia. The lab uses primary culture of human and mouse cells and employs genetic manipulation methods to investigate the function of novel proteins involved in ciliogenesis.
Select publications
The Translational Landscape of SARS-CoV-2-infected Cells Reveals Suppression of Innate Immune Genes
May 23, 2022
Puray-Chavez M, Lee N, Tenneti K, Wang Y, Vuong HR, Liu Y, Horani A, Huang T, Gunsten SP, Case JB, Yang W, Diamond MS, Brody SL, Dougherty J, Kutluay SB. The Translational Landscape of SARS-CoV-2-infected Cells Reveals Suppression of Innate Immune Genes. mBio. 2022 May 23:e0081522. doi: 10.1128/mbio.00815-22. Epub ahead of print. PMID: 35604092.
Kif9 is an active kinesin motor required for ciliary beating and proximodistal patterning of motile axonemes
May 9, 2022
Konjikusic MJ, Lee C, Yue Y, Shrestha BD, Nguimtsop AM, Horani A, Brody S, Prakash VN, Gray RS, Verhey KJ, Wallingford JB. Kif9 is an active kinesin motor required for ciliary beating and proximodistal patterning of motile axonemes. J Cell Sci. 2022 May 9:jcs.259535. doi: 10.1242/jcs.259535. Epub ahead of print. PMID: 35531639.
Variations in infection control practices suggest a need for guidelines in primary ciliary dyskinesia patient care
April 1, 2022
Caliskan AB, Horani A, Manion M, Brody SL. Variations in infection control practices suggest a need for guidelines in primary ciliary dyskinesia patient care. Pediatr Pulmonol. 2022 Apr;57(4):1072-1075. doi: 10.1002/ppul.25836. Epub 2022 Jan 28. PMID: 35043594.
Progress in Diagnosing Primary Ciliary Dyskinesia: The North American Perspective
July 16, 2021
O’Connor MG, Horani A, Shapiro AJ. Progress in Diagnosing Primary Ciliary Dyskinesia: The North American Perspective. Diagnostics (Basel). 2021 Jul 16;11(7):1278. doi: 10.3390/diagnostics11071278. PMID: 34359360; PMCID: PMC8304305.