Labs
Beigelman Lab
Avraham Beigelman, MD, MSCI
Avraham Beigelman's clinical and research interests include childhood asthma and food allergy. Specifically, the lab is interested in the research of asthma among pre-school children. Among these young children, he is investigating the factors that modulate disease activity, and the approaches for treatment of acute wheezing episodes. Currently, the lab's main research project is investigating whether we can prevent recurrent wheezing and potentially asthma, following severe RSV bronchiolitis. In addition, Beigelman is a co-investigator in the NHLBI's AshmaNet network, which is a multi-centered network investigating therapeutic approaches to childhood asthma.
Horani Lab
Amjad Horani, MD
The Horani lab research focuses on airway epithelial cell differentiation and regulation with special interest in cilia assembly and how it relates to impaired mucociliary clearance and the biology of primary ciliary dyskinesia. The lab uses primary culture of human and mouse cells and employs genetic manipulation methods to investigate the function of novel proteins involved in ciliogenesis.
Rubenstein Lab
Ronald Rubenstein, MD, PhD
The Rubenstein lab focuses on the mechanisms by which small molecules may improve the function of mutant proteins that cause disease due to abnormal biogenesis and trafficking. These studies initially focused on epithelial ion channels relevant to Cystic Fibrosis, and have expanded to address fundamental biologic questions related to the regulation of protein biogenesis and trafficking in a number of other diseases and conditions.