Ferkol Lab

Thomas W. Ferkol, MD

An American Lung Association Edward Livingston Trudeau Scholar and recipient of the Cystic Fibrosis Foundation (CFF) LeRoy Matthew’s Physician-Scientist Award, Thomas Ferkol’s research has focused on characterizing genetic and molecular factors that contribute to airway disease in cystic fibrosis and primary ciliary dyskinesia with past and continued support from the National Institutes of Health (NIH), CFF and March of Dimes.  He and his collaborators are currently examining the effects of viral infections on the microbiota, inflammation, lung function, and structural changes in the cystic fibrosis airway in infants, thus defining early pathogenic events in cystic fibrosis lung disease. (R01HL116211).  He is an investigator for the NIH-supported Genetic Diseases of Mucociliary Clearance Consortium (U54HL096458), a clinical research network to study rare diseases of the airways.  Ferkol is a member of a multidisciplinary research collaborative created at Washington University that defines clinical, functional, and structural phenotypes of patient subpopulations with known or suspected ciliopathies, a project funded by the Children’s Discovery Institute, studying the genetic and phenotypic spectrum of ciliopathies.  Most recently, his efforts have turned to understand the long-term impact of physiological and structural changes in the lung lead on respiratory outcomes in children with chronic lung diseases related to prematurity (U01HL101465).

Principal Investigator

Thomas W. Ferkol Jr., MD

Alexis Hartmann Professor of Pediatrics
Professor of Cell Biology and Physiology
Researcher, Pathobiology

Personnel

Projects

Influence of the enteric microbiome on the genesis of bronchopulmonary dysplasia

U01 HL101465 (Hamvas, Ferkol): The goal of this project is determine whether prospective, noninvasive physiologic measurements that reflect lung development predict adverse respiratory outcomes in children with chronic lung disease.

Genetic disorders of mucociliary clearance

U54 HL096458 (Knowles): The overall goal of this project is to establish a Rare Disease Clinical Research Center (RDCRC) and associated network of Airways Research Centers (ARC) to study rare diseases of the lung.

FDG-PET imaging in young cystic fibrosis patients

Cystic Fibrosis Foundation (Ferkol): The objective of this study is to examine the correlation between of positron emission tomography signal and pulmonary inflammation in adolescent children with cystic fibrosis.

Functional, structural, and genetic characterization of ciliopathies

Children’s Discovery Institute (Ferkol): The primary goal of this project is to characterize the functional, ultrastructural, and genetic defects of respiratory cilia in children with suspected ciliopathies.

Recent Publications

Association of Neonatal Hospital Length of Stay with Lung Function in Primary Ciliary Dyskinesia

June 3, 2022

Wee WB, Leigh MW, Davis SD, Rosenfeld M, Sullivan KM, Sawras MG, Ferkol TW, Knowles MR, Milla C, Sagel SD, Zariwala MA, Pullenayegum E, Dell SD. Association of Neonatal Hospital Length of Stay with Lung Function in Primary Ciliary Dyskinesia. Ann Am Thorac Soc. 2022 Jun 3. doi: 10.1513/AnnalsATS.202202-116OC. Epub ahead of print. PMID: 35657736.

Association between early respiratory viral infections and structural lung disease in infants with cystic fibrosis

May 3, 2022

Sanders DB, Deschamp AR, Hatch JE, Slaven JE, Gebregziabher N, Corput MK, Tiddens HAWM, Rosenow T, Storch GA, Hall GL, Stick SM, Ranganathan S, Ferkol TW, Davis SD. Association between early respiratory viral infections and structural lung disease in infants with cystic fibrosis. J Cyst Fibros. 2022 May 3:S1569-1993(22)00103-5. doi: 10.1016/j.jcf.2022.04.014. Epub ahead of print. PMID: 35523715.

Emerging Genotype-Phenotype Relationships in Primary Ciliary Dyskinesia

July 31, 2021

Brennan SK, Ferkol TW, Davis SD. Emerging Genotype-Phenotype Relationships in Primary Ciliary Dyskinesia. Int J Mol Sci. 2021 Jul 31;22(15):8272. doi: 10.3390/ijms22158272. PMID: 34361034; PMCID: PMC8348038.

Early Diagnosis and Intervention in Cystic Fibrosis: Imagining the Unimaginable

January 1, 2021

Coverstone AM, Ferkol TW. Early Diagnosis and Intervention in Cystic Fibrosis: Imagining the Unimaginable. Front Pediatr. 2021 Jan 11;8:608821. doi: 10.3389/fped.2020.608821. PMID: 33505947; PMCID: PMC7830672.

Understanding Primary Ciliary Dyskinesia and Other Ciliopathies

March 1, 2021

Horani A, Ferkol TW. Understanding Primary Ciliary Dyskinesia and Other Ciliopathies. J Pediatr. 2021 Mar;230:15-22.e1. doi: 10.1016/j.jpeds.2020.11.040. Epub 2020 Nov 23. PMID: 33242470; PMCID: PMC8690631.

Contact Us

Principal Investigator

Thomas W. Ferkol, MD
Phone: 314-454-2694
Fax: 314-454-2515
Email: ferkol_t@wustl.edu

U.S. mail

Ferkol Lab
Department of Pediatrics | Allergy & Pulmonary Medicine
Washington University School of Medicine
660 S. Euclid Ave.
Campus Box 8116
St. Louis, MO 63110